Beyeler SA, Naidoo R, Morrison NR, McDonald EA, Albarrán D, Huxtable AG. Maternal opioids age-dependently impair neonatal respiratory control networks. Front Physiol. 2023 Mar 16;14:1109754. doi:10.3389/fphys.2023.1109754. eCollection 2023. PMID: 37008014
Hocker AD, Morrison NR, Selby ML, Huxtable AG. Maternal methadone destabilizes neonatal breathing and desensitizes neonates to opioid-induced respiratory frequency depression. Front Physiol. 2021 Feb 25;12:604593. doi: 10.3389/fphys.2021.604593. eCollection 2021. PMID: 33716765
Beyeler SA, Hodges MR, Huxtable AG. Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity. Respir Physiol Neurobiol. 2020 Mar;274:103357. doi: 10.1016/j.resp.2019.103357. Epub 2019 Dec 30. PMID: 31899353
Morrison NR, Johnson SM, Hocker AD, Kimyon RS, Watters JJ, Huxtable AG. Time and dose-dependent impairment of neonatal respiratory motor activity after systemic inflammation. Respir Physiol Neurobiol. 2020 Jan;272:103314. doi: 10.1016/j.resp.2019.103314. Epub 2019 Oct 12. PMID: 31614211
Hocker AD, Huxtable AG. Viral mimetic-induced inflammation abolishes Q-pathway, but not S-pathway, respiratory motor plasticity in adult rats. Front Physiol. 2019 Aug 13;10:1039. doi: 10.3389/fphys.2019.01039. eCollection 2019. PMID: 31456699
Hocker AD, Beyeler SA, Gardner AN, Johnson SM, Watters JJ, Huxtable AG. One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats. Elife. 2019 Mar 22;8:e45399. doi: 10.7554/eLife.45399. PMID: 30900989
Huxtable AG, Peterson TJ, Ouellette JN, Watters JJ, Mitchell GS. Spinal protein phosphatase 1 constrains respiratory plasticity after sustained hypoxia. J Appl Physiol (1985). 2018 Nov 1;125(5):1440-1446. doi: 10.1152/japplphysiol.00641.2018. Epub 2018 Aug 30. PMID: 30161006
Huxtable AG, Kopp E, Dougherty BJ, Watters JJ, Mitchell GS. Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia. Respir Physiol Neurobiol. 2018 Oct;256:21-28. doi: 10.1016/j.resp.2017.12.004. Epub 2017 Dec 9. PMID: 29233741
Johnson SM, Randhawa KS, Epstein JJ, Gustafson E, Hocker AD, Huxtable AG, Baker TL, Watters JJ Gestational intermittent hypoxia increases susceptibility to neuroinflammation and alters respiratory motor control in neonatal rats. Respir Physiol Neurobiol. 2018 Oct;256:128-142. doi: 10.1016/j.resp.2017.11.007. Epub 2017 Nov 22. Review. PMID: 29174411
Hocker AD, Huxtable AG. IL-1 receptor activation undermines respiratory motor plasticity after systemic inflammation. J Appl Physiol (1985). 2018 Aug 1;125(2):504-512. doi: 10.1152/japplphysiol.01051.2017. Epub 2018 Mar 22. PMID: 29565772
Hocker AD, Stokes JA, Powell FL, Huxtable AG. The impact of inflammation on respiratory plasticity. Exp Neurol. 2017 Jan;287(Pt 2):243-253. doi: 10.1016/j.expneurol.2016.07.022. Epub 2016 July 27. Review. PMID: 27476100
Devinney MJ, Fields DP, Huxtable AG, Peterson TJ, Dale EA, Mitchell GS. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. J Neurosci. 2015 May 27;35(21):8107-17. doi: 10.1523/JNEUROSCI.5086-14.2015. PMID: 26019328
Huxtable AG, Smith SM, Peterson TJ, Watters JJ, Mitchell GS. Intermittent hypoxia-induced spinal inflammation impairs respiratory motor plasticity by a spinal p38 MAP kinase-dependent mechanism. J Neurosci. 2015 Apr 29;35(17):6871-80. doi: 10.1523/JNEUROSCI.4539-14.2015. PMID: 25926462
Alvares TS, Revill AL, Huxtable AG, Lorenz CD, Funk GD. P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro. J Physiol. 2014 Jul 15;592(Pt 14):3089-111. doi: 10.1113/jphysiol.2013.268136. Epub 2014 May 30. PMID: 24879869
Huxtable AG, MacFarlane PM, Vinit S, Nichols NL, Dale EA, Mitchell GS. Adrenergic α₁ receptor activation is sufficient, but not necessary for phrenic long-term facilitation. J Appl Physiol (1985). 2014 Jun 1;116(11):1345-52. doi: 10.1152/japplphysiol.00904.2013. Epub 2014 Feb 13. PMID: 24526581
Huxtable AG, Smith SM, Vinit S, Watters JJ, Mitchell GS. Systemic LPS induces spinal inflammatory gene expression and impairs phrenic long-term facilitation following acute intermittent hypoxia. J Appl Physiol (1985). 2013 Apr;114(7):879-87. doi: 10.1152/japplphysiol.01347.2012. Epub 2013 Jan 17. PMID: 23329821
Devinney MJ, Huxtable AG, Nichols NL, Mitchell GS. Hypoxia-induced phrenic long-term facilitation: emergent properties. Ann N Y Acad Sci. 2013 Mar;1279:143-53. doi: 10.1111/nyas.12085. Review. PMID: 23531012
Hayes DJ, Huxtable AG. Interpreting deactivations in neuroimaging. Front Psychol. 2012 Feb 7;3:27. doi: 10.3389/fpsyg.2012.00027. eCollection 2012. PMID: 22347207
Johnson SM, Turner SM, Huxtable AG, Ben-Mabrouk F. Isolated in vitro brainstem-spinal cord preparations remain important tools in respiratory neurobiology. Respir Physiol Neurobiol. 2012 Jan 15;180(1):1-7. doi: 10.1016/j.resp.2011.10.002. Epub 2011 Oct 12. Review. PMID: 22015642
Huxtable AG, Vinit S, Windelborn JA, Crader SM, Guenther CH, Watters JJ, Mitchell GS. Systemic inflammation impairs respiratory chemoreflexes and plasticity. Respir Physiol Neurobiol. 2011 Sep 30;178(3):482-9. doi: 10.1016/j.resp.2011.06.017. Epub 2011 Jun 25. Review. PMID: 21729770
Adachi T, Huxtable AG, Fang X, Funk GD. Substance P modulation of hypoglossal motoneuron excitability during development: changing balance between conductances. J Neurophysiol. 2010 Aug;104(2):854-72. doi: 10.1152/jn.00016.2010. Epub 2010 Jun 10. PMID: 20538779
Huxtable AG, Zwicker JD, Alvares TS, Ruangkittisakul A, Fang X, Hahn LB, Posse de Chaves E, Baker GB, Ballanyi K, Funk GD.Glia contribute to the purinergic modulation of inspiratory rhythm-generating networks. J Neurosci. 2010 Mar 17;30(11):3947-58. doi: 10.1523/JNEUROSCI.6027-09.2010. PMID: 20237265
Huxtable AG, Zwicker JD, Poon BY, Pagliardini S, Vrouwe SQ, Greer JJ, Funk GD. Tripartite purinergic modulation of central respiratory networks during perinatal development: the influence of ATP, ectonucleotidases, and ATP metabolites. J Neurosci. 2009 Nov 25;29(47):14713-25. doi: 10.1523/JNEUROSCI.2660-09.2009. PMID: 19940166
Funk GD, Huxtable AG, Lorier AR. ATP in central respiratory control: a three-part signaling system. Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):131-42. doi: 10.1016/j.resp.2008.06.004. Review. PMID: 18586120
Lorier AR, Huxtable AG, Robinson DM, Lipski J, Housley GD, Funk GD. P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro. J Neurosci. 2007 Jan 31;27(5):993-1005. PMID: 17267553